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Southdown sheep show defective clearance of bile acids, bilirubin and BSP, supporting a carrier defect in uptake of bilirubin, however they also have increased conjugated bilirubin, suggesting concurrent defects in canalicular transport (Engelking and Gronwall 1979)

This further prompts VEGF-dependent endothelial proliferation and vasculogenic mimicry (VM), where tumor cells self-organize into functional microvascular networks, bypassing traditional angiogenic pathways (Rashid et al., 2021)

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Comparative single- versus dual-incretin agonist pharmacology, run alongside GLP-1 (Sema) (single) and GLP-3 (Reta) (triple) to dissect receptor-specific effects

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