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In a review of 202 temporal bones, 11% were found to have a fibrous plug or fat plug obstructing the niche, while another 21% had adhesions or an extraneous (false) membrane [124, 126]

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When a second drug displaces a primary drug from its binding sites on plasma proteins, the unbound fraction For a low-extraction (restrictively cleared) drug, where u * CL int , The net effect is that the steady-state concentration of free drug, which is responsible for the therapeutic effect, remains largely unchanged, minimizing the risk of toxicity

Influence of glutamine and glycyl-glutamine on in vitro lymphocyte proliferation in children with solid tumors