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Correlations were tested using Pearson or Spearman tests according to data distribution

When H 2 O 2 increases there are several effects on one-carbon metabolism

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IR-61 (heptamethine) induces a reduction of mitochondrial damage and reactive oxygen species 130

Inflammatory cells produce oxidative stress by increasing the generation of reactive oxygen species (ROS), which in turn promote the production of pro-inflammatory molecules