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In atopic dermatitis mouse models, AES16-2M administration downregulated disease scores, ear thickness, serum IgE (a key marker of allergic disease), and TSLP

Mice in which the IRESNLSlacZSV40pA sequence was inserted immediately 3 to the STOP codon into the 3UTR of the VEGFA gene locus are hypomorphic for VEGFA (VEGFA hypo mice), but maintain galactosidase expression from the endogenous VEGFA gene locus (Damert et al , 2002)