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In addition to toxicity, a significant proportion of clinical trials fail for reasons other than safety, such as efficacy, strategic, and financial factors

G.KulhanM.TurklerC.KiremitliT.KiremitliS.et al (2019)

Epub 06/14/2023

it is a reflection of a shared thermodynamic and kinetic basis for the desired remedial action and the undesired biological harm

A more important part of the increased HF during aging can be attributed to a greater opportunity to be exposed to various stimuli, such as metabolic stress, hypertension, or ischemic injury [5]