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[PMC free article: PMC508574] [PubMed: 9435307] 36

doi: 10.1056/NEJM199901143400207

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Apolipoprotein E is synthesized in the retina by Mller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells

We have previously reported that GCH1 expression and BH4 levels in irradiated human skin and rat skin tissues are lower than that in the unirradiated counterparts, which impairs NO homeostasis and enhances ROS cascade (90)