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Drug resistance can occur due to genetically unstable human cancer cells, and drug-resistant features can either present before treatment (intrinsic) or develop after therapy (acquired)

doi: 10.1002/art.41420 [DOI] [PubMed] [Google Scholar] 35

Growth hormone peaks during deep sleep, and inadequate rest impairs insulin sensitivity, increases cortisol (which promotes fat storage), and reduces the bodys ability to recover from the metabolic stress of rapid weight loss