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Classical Hodgkin's lymphoma (HL), which accounts for approximately 10% of all diagnosed lymphomas, is a B-cell lymphoid disease that is subdivided into classical HL and nodular lymphocyte-predominant HL [6]

Botox is an off-label treatment (not officially FDA-approved for this use but supported by research and clinical practice) that can help by blocking pain signals and relaxing the muscles around the affected nerve

Thyroid hormones act both on liver, regulating hepatic lipid metabolism and hepatosteatosis, and in adipose cells, increasing energy expenditure and enhancing lipolysis (160, 161)

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The spheres were washed twice and stained with 1:500 PI solution (Bio-Sciences) supplemented with 250 g/mL RNAse A (Qiagen) and Hoechst nuclear counterstain (2 g/mL) (Bio-Sciences) for 30 min protected from light, at room temperature