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Heffernan et al., The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and 3-AR Knock-Out Mice, Endocrinology, vol

Due to the toxic effects of homocysteine on blood vessels, high homocysteine is linked to increased risk of cardiovascular and microvascular diabetes complications

Compound AOD-9604 Class Synthetic hGH C-terminal fragment (16 aa) FDA Status Not FDA-approved Evidence Strength Phase 2b primary endpoint missed

Key finding: AOD 9604 stimulated adipocyte lipolysis 3.8-fold via hormone-sensitive lipase activation

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