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Description

Expression levels of target genes were normalized against the expression of -actin, a housekeeping gene

Mehendale HM (1990) Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism

Freedman, J

Previous studies have demonstrated that prolonged ID reduces Nrf2 protein expression and decreases autophagic flux in the mouse hepatocyte cell line AML12 [17]

The pharmacological and genetic antagonism of PKC protected against APAP-mediated liver injury by inhibiting JNK activation, while JNK1 and JNK2 silencing in vivo decreased APAP-mediated PKC translocation to mitochondria, unraveling a feed-forward mechanism involved in APAP hepatotoxicity