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Nat Rev Immunol (2016) 16:55365.10.1038/nri.2016.70 6 BuckMDSowellRTKaechSMPearceEL

Kadioglu A, Sanli O, Akman T, Ersay A, Guven S, Mammadov F

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Since interferon- (IFN-) was approved for the treatment of RRMS in 1993, substantial progress has been made in targeting peripheral immune-driven inflammatory processes through a range of anti-inflammatory and immunomodulatory therapies (Koch-Henriksen and Sorensen, 2000)