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Limiting caffeine intake to moderate levels can help maintain the balance needed for glutathione to work effectively

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)