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Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system This study aimed to assess the effects of short-term GW501516 administration on pro-inflammatory markers in white adipose tissue (WAT) and hepatic stellate cells (HSCs), as well as liver lipogenesis and insulin resistance in response to high-fructose diet (HFru)-induced ACE/AT1r axis activation

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R.EspinosaJ.Gonzlez-FernndezP.Jaime-FernndezE.TraversoJ

These events not only directly trigger chondrocyte death and extracellular matrix degradation but also exacerbate bone metabolic imbalance through intricate signaling networks

G.PollockD

In the end, it ameliorated myocardial function in diabetic mice