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Drugs repurposed: an advanced step towards the treatment of breast cancer and associated challenges

In overdose, TCAs are associated with the 3 Cs: coma, convulsions, and cardiac arrhythmias

This astrocytic pathway is GM-CSF-driven, secreted mainly by activated T lymphocytes

Science 304:13381340 Shen Q, Wang Y, Kokovay E, Lin G, Chuang SM, Goderie SK, Roysam B, Temple S (2008) Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions

Brain meets body: the blood-brain barrier as an endocrine interface

While App knockin mouse shows no significant neurodegeneration and neuronal loss, it shows synaptic loss and reduction of a part of neuronal cells including active place cells around A plaques 41,60