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Ex vivo studies have shown that increasing glucose metabolism with dichloroacetate, a pyruvate mimetic that activates PDH, increases glycolytic flux and improves LV function.87 This has been followed up in vivo , where dichloroacetate administration returned rates of glucose metabolism of diabetic rats to control levels.88 This occurred alongside reversal of impaired diastolic function and normalisation of blood glucose concentrations

Clinical Nutrition ESPEN , 37, 9-23

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examined the impact of ALC (50 mg/kg/day for a month) on the HPG axis in female rats and found that serum LH and prolactin levels were increased during the proestrous and estrous phases, while serum E 2 levels were increased during the estrous phase of the cycle