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Havelund S, Plum A, Ribel U et al (2004) The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin

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This causes cells to be very large and abnormally shaped

Concerns about gastric comfort also apply to GLP-1 peptide Cagrilintide, but there are no thyroid-related warnings like there are with GLP-1 agonists