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Macip, A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageing

Studies have shown that serum IL-6 levels are significantly elevated in patients with ALD and are directly linked to liver dysfunction and the severity of ALD complications [142, 143]

This would presumably rely on its spirosuccinimide moiety, which bears resemblance to both the glutarimide motif present in thalidomide analogs and the asparagine cyclic imide modification proposed to be a natural degron recognized CRBN 4244

doi: 10.1080/87559129.2025.2550596 514 ZimmermannPCurtisN

Water, Niacinamide, Dipropylene Glycol, Glycerin, Propanediol, Butylene Glycol, Hydroxyethyl Urea, Diethoxyethyl Succinate, Hydroxyacetophenone, Caprylyl Glycol, Polyglyceryl-10 Laurate, Betaine, Panthenol, Ethylhexylglycerin, Gluconolactone, Sodium Polyacrylate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Sodium Citrate, Citric Acid, Maltodextrin, 1,2-Hexanediol, Gardenia Florida Fruit Extract, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Ascorbic Acid, Pantolactone, Tocopherol, Capryloyl Salicylic Acid, Tranexamic Acid, Tremella Fuciformis Extract, Caprylic/Capric Triglyceride, Ascorbyl Glucoside, Ubiquinone, Hydrogenated Lecithin, Magnesium Chloride, Alcohol, Glutathione, Polysorbate 80, Calcium Gluconate, Pyridoxine HCl, BHT, Yeast Extract, Cyanocobalamin, Disodium EDTA *Due to changes in production, the manufacturer may, in rare cases, make short-term changes to the ingredients used