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Predictive biomarkers such as baseline NAb titers and ISG signatures will become more widely used to anticipate treatment responses and therapeutic efficacy ( + tumor-infiltrating lymphocytes (TILs) and PD-L1 expression, as well as the rate of circulating tumor DNA (ctDNA) clearancewill facilitate real-time efficacy assessment and dose adjustment ( Table 8 Emerging biomarkers for Oncolytic Virus (OV) therapy in malignant melanoma

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Nonetheless, when reduced to the nanoscale, these materials may interact with biological systems in novel ways, and our understanding of their long-term toxicological profile is incomplete (198, 199)

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