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ProteiNorm (Graw et al., 2020) was used to evaluate the quality of MS2 intensities and variance stabilizing normalization was applied (Huber et al., 2002)

Both IGF-1 splice variants are incredibly fragile biological proteins

(2021) [61] with 30 patients aged between 3 and 7 who were categorized as severe ASD with an average CARS score of 50 (range 4055.5)

Accordingly, other aspects of AD pathology, more closely related to the clinical symptoms of AD are currently investigated like the already mentioned synaptic deficits and other measures of neurodegeneration and their relationship to impairment of mitochondrial function

10.1016/j.jacbts.2020.11.002 32 LiuM.DudleyS

These changes may also promote programmed cell death in activated fibroblasts and other pro-fibrotic cells, thereby reducing fibrogenic activity