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5 Summary and future perspectives In summary, in the pathogenesis of DR, prolonged hyperglycemia affects the normal physiological function of RMCs, leading to the disturbances in the retinal water-ion balance, disruption of the BRB, imbalance in the homeostasis of the retinal microenvironment, and the secretion of pro-inflammatory cytokines and chemokines following RMCs overactivation

(1987) Aspartame and susceptibility to headache

Free Radic Biol Med 15: 195202

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doi: 10.1097/00004583-198811000-00010 [DOI] [PubMed] [Google Scholar] 428