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Co-treatment with mercury and NAC significantly reduced the expression of MPO (2.49-fold, Table 2), HIF1 (2.12-fold, Table 3), MMP2 (1.94-fold, Table 4), TIMP1 (1.92-fold, Table 5), TIMP2 (1.92-fold, Table 6), NOS (2.00-fold, Table 7), and FN1 genes (1.85-fold, Table 8), while increasing SOD expression (0.76-fold, Table 9) compared to rats treated with a continuous mercury exposure alone

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Bone tissue is constantly remodeled through a process of coupled bone turnover: briefly, osteoclasts (bone-breaking cells) resorb bone tissue and then osteoblasts fill the resorption sites with new tissue [45]

Procell, Wuhan, China) were cultured in DMEM/F12 medium supplemented with 10% fetal bovine serum (FBS) in a cell incubator (Thermo Fisher Scientific, Waltham, USA) at 37C with 5% CO 2

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Among these, the downregulation of circSnx12 induces iron overload by releasing miR-224-5p to downregulate FTH1 levels [139]