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Animal and in vitro studies have reported a wide range of Mn-induced pulmonary effects, including lung damage, inflammation, alveolar macrophage infiltration, and oxidative stress ( Additionally, excessive Mn has been linked to metabolic disorders, including type II diabetes, obesity, and cardiovascular disease, with oxidative stress proposed as a key contributing factor (Li and Yang, 2018)

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doi: 10.3389/fimmu.2023.1166214 5 ZongW-XRabinowitzJDWhiteE

doi: 10.3389/fmicb.2020.01920 189 ShankarSKMahadevanASundaramCSarkarCChackoGLanjewarDNet al

Each COA documents component identity by HPLC and mass spectrometry, purity per component (typically 99%), and, where applicable, sterility and endotoxin testing, plus lot-specific storage guidance

Folatespecifically L-methylfolatesupports the methylation process and gene expression