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This results in preventing bile acid reabsorption thus decreasing the bile acid pool, which in turn reduces FGF15/19 and increases the gene transcription of the bile acid synthesis rate-limiting enzyme, CY7A1

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Shaping of human germline IgH repertoires revealed by deep sequencing

However, while many clinical trials failed to show a reduction in cardiovascular event outcomes, these trials used a secondary-prevention population currently on a polypharmacy of drugs including statins, beta-blockers, aspirin and ACEI

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