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230 In adult mice, knockout of mitochondrial Rieske iron-sulfur protein (RISP) leads to an increase in SAM, which is necessary for methyltransferase activity, resulting in proliferative remodeling of the heart with a doubling of cardiomyocyte numbers, although cellular hypertrophy does not occur 231 (Fig

4fh) suggesting that GAPDH inhibition-induced methylglyoxal elevation can impair the respiratory burst

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doi:10.1182/bloodadvances.2017013979 Autier P, Mullie P, Macacu A, et al.Effect of vitamin D supplementation on non-skeletal disorders: a systematicreview of meta-analyses and randomised trials