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Zhong et al., 2009

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Role of GM in drug metabolism It is well-known that the pharmacokinetic (PK) properties of available drugs differ according to many variables, e.g., chemical structure, lipid solubility, prodrugs versus active drugs, drugs with enteric-release formulae, site of absorption, gastrointestinal pH, way of metabolism, route of elimination, and drugs substrate for enterohepatic circulation

Also, Akkermansia muciniphila (WO2021008149A1) (138) was tested after fecal microbiota transplantation from depressed patients into C57BL/6 mice

Because glutathione is a substance your body already produces, adverse reactions are uncommon

Meanwhile, the application of natural products in nasal drug delivery has gained increasing emphasis as one of the hotspots in drug development, since natural products generally have fewer side effects and better biocompatibility compared to chemically synthesized drugs