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Its believed that the skins gradual decline in glutathione is one factor contributing to external signs of ageing

Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions

4.3 Translational DoseResponse Considerations and Human Attainability While numerous in vitro studies report IC 50 values demonstrating anti-proliferative or pro-apoptotic activity of natural compounds in breast cancer cell lines, the clinical relevance of these concentrations requires careful evaluation

Santacroce, G., Gentile, A., Soriano, S., Novelli, A., Marco Vincenzo Lenti, & Antonio Di Sabatino

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Thereby, miRNAs are responsible for reduced sensitivity to treatments and can also serve as prognostic markers for certain types of cancer cells [92]