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In these studies, a chronic low dose of aflatoxin produced precancerous lesions in monkeys fed 5% casein but not in those fed 20% casein

10.1073/pnas.1500545112

In accordance with such a variety of functions, isoforms of this heterogeneous protein family are found in many prokaryotes as well as in the cytosol, nucleus, mitochondria, chloroplasts and/or secretory pathway of eukaryotes 1,2,3,4,5,6,7,8

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This gradual increase minimizes gastrointestinal side effects such as nausea and diarrhea