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Mitochondria, the primary organelles responsible for maintaining redox balance in astrocytes, are not only concentrated in the cell body but also found near synapses, where they regulate oxidative stress

BBB pathophysiology-independent delivery of siRNA in traumatic brain injury

K.Vailati-RiboniM.AlharthiA.BatistelF.LoorJ

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Upon activation, NLRP3 oligomerizes and recruits ASC via PYD-PYD binding, forming a scaffold that transports procaspase-1 molecules into proximity through the CARD-CARD interaction

Then, 1.5 10 6 cells were seeded into a six-well plate in 2.5 ml of SILAC medium (typically two wells per condition)