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Mov Disord 24(9):13391343 Al Mutairi F (2020) Hyperhomocysteinemia: clinical insights

Tizanidine , an imidazoline derivative, is a central-acting noradrenergic alpha-2 receptor agonist that blocks the release of excitatory amino acids like glutamate and aspartate from spinal interneurons and increases presynaptic inhibition of motor neurons with the greatest effect on spinal polysynaptic pathways [49]

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[DOI] [PubMed] [Google Scholar] 136.Houstis N, Rosen ED, Lander ES

Notably, animals treated with both PEG and ML162 displayed the best pinprick scores among the 4 groups (Fig