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HP 13 C MR via dissolution dynamic nuclear polarization (dDNP) is an emerging imaging technology that allows direct visualization of metabolic conversion of 13 C-enriched molecules, and has been applied extensively to study metabolism in cells, tissues, animal models, and patients 22,23,24

For example, urine metabolomics analysis revealed that metabolites associated with the ferroptosis signaling pathway were uniquely expressed in patients with diabetic nephropathy, indicating that ferroptosis could be a key mechanism in disease progression [80]

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