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However, the role of BAT PNPLA2 in maintaining thermogenesis has been recently challenged with tissue-specific gene knockout (KO) models

GHD is severe in GH1 or GHRH-R gene defects and in some children with congenital GHD as well as after treatment of brain tumors with radiation therapy

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Cette carence peut tre due diffrentes causes, comme la maladie de Biermer (pouvant tre li une problmatique au niveau de la paroi de lestomac, une carence du facteur intrinsque, ), une gastrectomie (retrait partiel ou total de lestomac), une infection Helicobacter Pylori, une insuffisance pancratique ou encore une maladie inflammatoire de l'intestin