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The World Health Organization (WHO) estimates that 10.6 million people were infected with Mtb and 1.3 million died of TB in 2022 ( The immune response to Mtb in TB patients ( In this work, we immunized mice with the sterile culture medium supernatants (SCMS) of Mtb H37Rv to produce monoclonal antibodies (mAbs) aiming to identify previously undervalued immunogenic antigens