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Independent of the species that triggers aggregation, it is generally accepted that a gain-of-function toxicity of the expanded ATXN3 protein contributes highly to SCA3 pathology

Any water with a pH lower than 7.0 is said to be acidic and water above 7.0 is called basic, as shown in the pH scale below

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Reconstituted solutions should be prepared in sterile bacteriostatic water or physiological saline and used promptly for research assays