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B Cells and Humoral Immunity in SSc B cells participate deeply to SSc pathogenic events both as precursors of autoAb producing cells and as inflammatory cells infiltrating tissues undergoing fibrosis, namely the skin and the lung [97, 158] where they release cytokines and may influence the behavior of fibroblasts and other mesenchymal cells [159] (Fig

The compound also appears to interact with the growth hormone receptor signaling cascade, with data from rodent models suggesting upregulation of GH receptor expression in injured tissues, potentially linking BPC-157 activity to IGF-1-mediated tissue maintenance pathways under experimental conditions

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