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Recognition of early signs becomes crucial for effective intervention

On the other hand, oligomeric -synuclein co-localizes with the F 1 Fo ATP synthase and causes oxidative modification of its subunit, the key subunit that interacts with ADP and ATP [24]

Abbreviations AADAC: Arylacetamide deacetylase ALT: Alanine aminotransaminase APAP: Acetaminophen AST: Aspartate aminotransferase CCl 4 : Carbon tetrachloride CP: Ceruloplasmin DFO: Deferoxamine DILI: Drug-induced liver injury EDTA: Ethylenediamine- N , N , N , N -tetraacetic acid disodium ER: Endoplasmic reticulum Fer-1: Ferrostatin-1 GPX4: Glutathione peroxidase 4 HO1: Heme oxygenase 1 NQO1: NAD(P)H quinone oxidoreductase 1 MDA: Malondialdehyde MLM: Mouse liver microsomes MLS9: Mouse liver S9 fractions SDS: Sodium dodecyl sulfate SLC7A11: Solute carrier family 7 member 11 TBA: 2-Thioberbituric acid References Attia SM (2010) Deleterious effects of reactive metabolites

Ferrannini E, Baldi S, Frascerra S, Astiarraga B, Heise T, Bizzotto R, et al

Hyperbaric oxygen and hyperbaric air treatment result in comparable neuronal death reduction and improved behavioral outcome after transient forebrain ischemia in the gerbil

The peroxidase-conjugated goat anti-rabbit (Sigma-Aldrich, A6154) or peroxidase-conjugated goat anti-mouse (Sigma-Aldrich, A4416) second antibodies were diluted 1:10,000 and incubated 1 h at RT