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J Pathol 217(4):571580 Shim WS, Ho IA, Wong PE (2007) Angiopoietin: a TIE(d) balance in tumor angiogenesis

First step evaluation includes brain CT scan with additional venography and lab test like CBC, Retic counts, peripheral blood smear, PT, aPTT, fibrinogen, D-dimer test, antiphospholipid LDH level, paroxysmal nocturnal screening, and ADAMTS-13 should be done for suspected cases