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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Chi X, et al

Osler described skin lesions (polymorphic) in conjunction with arthritis and kidney failure by the early 1900s

Individual responses vary, and not everyone will experience these effects

American Academy of Clinical Toxicology (February 2013), "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation , American College of Medical Toxicology and American Academy of Clinical Toxicology, retrieved 5 December 2013 David Rakel, Integrative Medicine 5th edition, Elsevier, 2023

Studies on ALDH2 -deficient mice have shown that hepatocytes can produce harmful oxidized mtDNA in large quantities, which are then transferred to adjacent hepatocytes via extracellular vesicles

In such a context, the significance of PGK1 Kcr and ECHS1, as well as the identification of related signaling pathways involved in this regulation, warrant further exploration