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Additionally, it has been suggested from studies that estrogens enhance the porphyrin inducing activities of other agents making women more vulnerable to environmental exposures than their male counterparts [15, 16]

British Journal of Clinical Pharmacology, 2006

In mammals, as PER and CRY proteins accumulate, they dimerize, enter the nucleus, and inhibit CLOCK:BMAL1 activity, forming the negative feedback loop that is central to circadian timekeeping (Sehgal et al., 1994