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The same paper is often cited by coffee enema proponents

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10.3892/or.2014.3342 208 YuS.WangX.HeX.WangY.GaoS.RenL.et al (2016)

Knockout mice lacking wild-type and neuronal NO synthase have much reduced quantities of POMC immunoreactivity in their arcuate nuclei and pituitaries compared to wild-type mice (195,197)