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Some studies have identified changes in the gut microbiota as a potential factor in the pathophysiology of obesity and asthma

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In the 48-week Phase 2 MASH trial (NCT04771273) published in the New England Journal of Medicine, histologic improvement in MASH without worsening of fibrosis occurred in up to 62% of survodutide-treated participants (at 4.8 mg) versus 14% on placebo, with a significant dose-response

However, B12 shots are not a weight-loss magic bullet and must be combined with diet and exercise

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