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Long-range Coulomb interactions were handled using the particle mesh Ewald summation method (PME) 54 by setting the mesh spacing to 1.0

As a result of prolonged inflammation in IBD, tissue fibroblasts are activated and transformed into myofibroblasts, capable of producing ECM, and smooth muscle -actin (- SMA) is the known myofibroblast formation marker in GI tract

However, traditional treatments have extensive clinical validation while BPC-157 remains experimental

It is classified as an unapproved drug and is on the U.S

BPC-157 is a synthetic peptide derived from a protein found in the stomach, best known in repair research for healing tissue and tendons, protecting the gut, and supporting recovery

The flow chart in the supplementary material illustrates the literature search (Additional file 2: Figure S2)