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While targeting GPX4 holds promise in cancer treatment, a challenge arises from its widespread expression in both cancer and immune cells, which can potentially cause side effects when using traditional GPX4 inhibitors

We recommend using prophylactic medications in moderatetosevere CVS and offering abortive medications to all patients to terminate an acute attack

Lucey has received research support from Roche Pharmaceuticals, and Schering Plough

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