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While overdosing on vitamin B12 is said to be highly unlikely, experts believe it is possible to have elevated B12 levels

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Four major 56-week phase III randomized, double-blind, placebo-controlled trials have shown the therapeutic effect of SR (COR-I, COR-II, COR-BMOD, COR-DIABETES) in different dosage combinations (see Table 6)

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The uricosuric agents targeting the URAT1 transporter, such as lesinurad and dotinurad, along with the formulation of oral combination therapies comprising xanthine oxidase inhibitors and uricosuric agents, is poised to improve the attainment of the target serum uric acid level of less than 6 mg/dL