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39 Similarly, high levels of GCs can also activate microglia, creating a vicious cycle

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A recent in vitro study showed that PINK1-dependent phosphorylation of Ser111 of Rab8A antagonistically regulates the phosphorylation of Thr72 of Rab8A by LRRK2 (Vieweg et al., 2020), suggesting that there might be even closer crosstalk between the two master kinase

35 The typical dose is 9 mg once daily for up to eight weeks

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Practical protocols and real-world considerations Clinical trial data is generated under controlled conditions with careful patient selection, regular monitoring, and professional oversight

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