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Regarding the different isoforms of ARG, ARG2 has a distinct intracellular localization compared with ARG1

When ferroptosis threatens, cells deploy multiple antioxidant defense systems to halt lipid-peroxidation chain reactions

Sod2 +/- mice crossed with Apoe -/- mice have increased atherosclerosis compared to control Apoe -/- mice (410), but there is little effect on atherosclerosis of crossing Sod3 -/- mice with Apoe -/- mice (411)