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doi: 10.1016/j.transproceed.2008.10.009 56 HashimotoH.VertinoP

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and patients with glutathione-S-transferase M1 (proinflammatory-cytokine producer macrophages) null and M1 and T1 (Type 1 helper CD4 + lymphocytes) double null polymorphisms had increased mortality suggesting that antioxidant therapy becomes fundamental for those patients (109)

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For example, sulfoxidation of S -allyl-L-cysteine and S -benzyl-L-cysteine and, at a lower rate, S -(1,2-dichlorovinyl)-L-cysteine and S -(1,2,2-trichlorovinyl)-L-cysteine, was catalyzed by flavin monooxygenases (Ripp et al

83 In vitro, knockdown of TYK2 in murine and human MPNST cells significantly increased cell death, while knockdown in vivo led to a decreased tumour volume in a subcutaneous mouse model, supporting a role for TYK2 in driving MPNSTs