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The first step in predicting these physical properties is determining the type of IMFs that are present, which we discussed in the previous section

In practice, the optimal dose schedule likely varies by body weight, metabolic baseline, genetic factors, and individual receptor sensitivity

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Depending on the type of pathophysiologic process, water and sodium may be lost in physiologic proportion or lost disparately, with each type producing a somewhat different clinical picture, designated as normotonic (mostly isonatremic), hypertonic (mostly hypernatremic), or hypotonic (always hyponatremic) dehydration