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However, the minimal difference in the phenotypes between wild-type and OCTN1 / mice makes it demanding to understand the exact physiological role of OCTN1

for example, lactate promotes the proto-oncogenic M2-like polarization of TAMs, while through metabolic normalization, TAMs can transform into an anticancer M1 phenotype in preclinical models [214, 215]

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LEfSe analysis showed controls enriched in Enterorhabdus , Prevotella buccalis , and Helicobacteraceae (sows) and Eubacterium coprostanoligenes (piglets), whereas NR groups were enriched in Ruminococcus , Bacteroidales_bacterium_H4 , Intestinibacter , and Rhodospirillales (sows), along with Bifidobacterium , Subdoligranulum , Rikenellaceae_RC9 , Clostridium butyricum , and Succiniclasticum (piglets) (Fig