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The increase in ROS can also affect the apoptosis and metabolism of glioma cells via the JNK-regulated metabolic pathway and ataxia telangiectasia mutated (ATM)-Yes-associated protein 1 (YAP1)-driven apoptotic pathway ( Celastrol is one of the most important active ingredients of the traditional Chinese medicine Tripterygium wilfordii , which activates the JNK pathway and ROS production and inhibits the activities of mechanistic targets of rapamycin (mTOR) and Akt kinases, significantly increasing apoptosis and autophagy in glioma cells (Liu et al., 2019)

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Using Parkin-null (Park / ) flies, a study showed that folic acid supplementation improved the motor dysfunction and decreases hydrogen peroxide and glutathione redox imbalance [175] where as in fly homozygous for Parkin mutation (c00062), folic acid supplementation improved the mortality, locomotory defect, oxidative stress by alleviating mitochondrial dysfunction associated with Parkin mutation [176]

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