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For example, women with obesity were more predisposed to severe L-C19 at one year after discharging due to hormonal, pro-inflammatory and metabolic state (176)

[DOI] [PMC free article] [PubMed] [Google Scholar] 287.Vitale I., Pietrocola F., Guilbaud E., Aaronson S.A., Abrams J.M., Adam D., Agostini M., Agostinis P., Alnemri E.S., Altucci L., et al

Since MHCII antigen processing occurs throughout the phagolysosomal system, we speculate that the disruption of lysosomes by IAPP aggregates may directly interfere with MHCII antigen processing

Our group also recently demonstrated that cancer cells increase SHMT2-driven dependency on the ser/gly synthesis pathway upon radiotherapy treatment